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Figure 3


Fig. 3. The {alpha}2ß1 integrin is important for initial fibroblast adhesion to collagen I. Equal numbers of wild-type (open circles) and {alpha}2-deficient (closed circles) fibroblasts were seeded on triplicate wells coated with increasing concentrations of collagen I and for different periods of time as indicated. After 15 minutes, adhesion of {alpha}2-deficient fibroblasts to collagen I was markedly decreased compared with normal cells and partially rescued at longer incubation times. The means ± s.d. of triplicate wells are shown.