Fig. 9. Podosome rosettes can be a periodically emerging structure. (A,C,E) Diversity of the profiles exhibited by expansion/contraction rates E(t). (A) Contraction profile without rosette expansion (on flexible substratum). (C) alternating symmetrical expansion and contraction phases with decreasing signal amplitude (on rigid substratum). (E) Alternating asymmetrical expansion and contraction phases with decreasing signal amplitude (on rigid substratum). (B,D,F) Associated Fourier transforms of the E(t) time series in A-C, respectively.