Fig. 7. The ascidian (Ciona) type I Ins(1,4,5)P₃R (IP₃R1) sequence has diverged at the Cdk1 phosphorylation sites, which are conserved in Drosophila, Xenopus and human. Sequences are aligned, with differences outside the consensus S/T P motif shown in blue and differences in the consensus itself shown in red. Human mouse and Xenopus alignment is from Malathi et al. (Malathi et al., 2003). GenBank accession number for Drosophila is A43360, and the Ciona sequence was obtained from Nori Satoh's Ciona genome database, accession number ci0100150586.