Fig. 5. Increased trabecular bone volume in old Smad4 mutant mice. (A-D) Sections of tibias (A,B) and sagittal sutures (C,D) of 1-year-old Smad4 mutant (B,D) and control mice (A,C). (E-H) Quantitative histomorphometric measurements were performed on the spongiosa at the proximal tibias of 11-month-old female mice. All values were mean ± s.d. of five control (white bars) or Smad4 mutant mice (grey bars). ^*P<0.05; ^**P<0.01. Bar, 350 µm (A,B); 100 µm (C,D).