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Figure 8


Fig. 8. Diagram showing the possible mechanism of ephrin-B1-mediated stimulation of MMP-8 secretion and cell invasion. When ephrin-B1 is stimulated by EphB receptors, Arf1 GTPase is activated through signaling mediated by the C-terminus ephrin-B1, which may stimulate the transport of MMP-8 for extracellular release. The increase of secreted MMP-8 triggers the degradation of extracellular matrix (ECM) and cleavage of ephrin-B1.