Fig. 6. (A) Tether length vs time, calculated using equation 2 (see Materials and Methods). The tether grows much faster after cholesterol enrichment (dotted line) compared with the control (solid line) and cholesterol-depleted (dashed line) cases. The curves for control and cholesterol depletion are similar. (B) The estimated force acting on a bond between an endothelial tether and a leukocyte. After cholesterol enrichment (dotted curve), initially, the bond force decreases much faster than in the control (solid curve) and cholesterol depleted (dashed curve) cases. The curves for the control and cholesterol depletion are again similar.