Fig. 8. Roles of CDK11^p58 in regulation of sister chromatid cohesion during mitosis. CDK11^p58 protects sister-chromatid cohesion at both the arms and at the centromere. The dashed circles denote the hypothetical protective action of CDK11^p58 on chromosome cohesion rather than localization of CDK11^p58 to the chromosome. SAC represents the spindle checkpoint. Premature dissociation of Bub1 and cohesion complexes occurs in CDK11-depleted cells. ^*Plk1 binding to kinetochore is reduced in CDK11 RNAi cells (Petretti et al., 2006), which may also influence chromosome cohesion.