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Figure 1


Fig. 1. Polypeptide sequences and predicted transmembrane topology for human, Drosophila and yeast cornichon proteins. (A) Alignment of the amino acid sequences CNIH, CNIH2, CNIH3 and CNIH4. The identity of CNIH with each of the other paralogs is: 105/159 (66%) with CNIH2; 109/160 (68%) with CNIH3; 45/118 (38%) with CNIH4. (B) Alignment of CNIH, Drosophila Cni (dCni) and Erv14. The identity of CNIH with each ortholog is: 96/144 (66%) with dCni and 45/137 (32%) with Erv14. Predicted transmembrane domains are underlined. The conserved `Cni domain' is boxed. Identical residues are in red.