Fig. 6. Effects of PrPC depletion on proteasome activity and cellular ROS in Caco-2 and HT-29 cells. (A) Western blot of PrPC levels in siRNA-treated Caco-2 and HT-29 cells and quantification of this blot. (B) The activity of proteasome measured 72 hours after transfection with oligonucleotides in Caco-2 and HT-29 cells. (C) ROS levels measured 72 hours after transfection with oligonucleotides in Caco-2 and HT-29 cells.