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Figure 2


Fig. 2. Schematic diagram showing mechanism of TI at the IME4 locus in yeast. The IME4 locus is transcribed by a sense and an antisense transcript in haploid cells of the a or {alpha} mating type because the MATa-{alpha} repressor that represses the antisense transcript is not present. As a result, IME4 protein is not produced. In diploid MATa/{alpha} cells, MATa-{alpha} represses transcription of the IME4 antisense transcript. This allows production of IME4 and the initiation of meiosis.