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Figure 5


Fig. 5. Senescence-associated beta-galactosidase assay performed on MSCs transduced with the recombinant adenoviruses indicated in Table 2. Assays were performed 3 days after transductions. Ad-YH47 and Ad-RG2 indicate adenoviruses carrying mutated E1A isoforms that inhibit p53 (p53 {perp}) and Rb (Rb {perp}), respectively. The picture shows several senescent cells as detected with beta-galactosidase assay. White asterisk, a typical flat large senescent cell.