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Figure 2


Fig. 2. The sequences showing the unique sites of miRNA::mRNA complementarity between miR-1 and HSP60 or HSP70, and between miR-133 and caspase-9 (Casp9) for both human (H) and rat (R) genes. The matched base pairs are bold and connected by a vertical line and the G:U/U:G wobble is indicated by bold letters connected by dots. The GenBank accession numbers of the genes are indicated in the brackets and the positions of the target sites are numbered. Note that there is only a single target site for miR-1 in HSP60 or HSP70 and the complementarity is limited to the 3'UTRs of these genes, whereas there are multiple target sites in Casp9 and the sites are distributed throughout the whole mRNA sequence.