Fig. 7. Cohesin SMCs remain associated with chromosome arms when cores break down prematurely in the absence of ORD activity. Shown is a chromosome spread from the ovary of an ord^null female stained for SMC1/3 (white), C(3)G (magenta) and DNA (blue). In a nucleus that contains fragmented SMC1/3 and C(3)G staining (left), diffuse chromatin-associated SMC1/3 signal is still visible, indicating that SMCs remain associated with chromosome arms when cores break down in the absence of ORD activity. Note that diffuse cohesin SMC signal in this nucleus is similar in intensity to the SMC1/3 staining in the adjacent pro-nurse cell that did not build SC (compare signal intensity within the two circles). Bar, 5 µm.