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Figure 2


Fig. 2. RASSF1 gene locus and domain structure of the different RASSF1 isoforms. (A) The RASSF1 gene locus is characterized by eight exons (boxed regions) and two different promoters (arrows) with two associated CpG islands (black bars). Black boxes represent coding regions and white boxes are non-coding regions. (B) Schematic representation of the different RASSF1 isoforms. C1/DAG, conserved region 1 diacylglycerol-binding domain; ATM, ATM-kinase consensus phosphorylation sequence; RA, RalGDS/AF6 Ras association domain; SARAH, Sav/RASSF/Hpo interaction domain. The position of each domain (as outlined in the Swiss-Prot/TrEMBL database) is indicated above each isoform and the number of amino acids in each isoform is shown on the right.