Fig. 1. Distribution and sequence comparisons of TPR motifs in putative Apc7 orthologues. (A) Distribution of TPRs in the human Apc7 subunit (Hs), the Drosophila CG14444 gene product (Dm), and predicted proteins from Arabidopsis thaliana (At; accession no. NP 850309) and Apis mellifera (Am; accession no. XP 396165). The asymmetric rectangular symbols represent single TPR motifs. (B) Sequence alignment of seven TPR motifs of the Drosophila Apc7 protein. The TPR consensus sequence is shown below the alignment. Residues matching the consensus are in bold type and highlighted in grey (also in C). Residues are conserved only at the consensus positions but, even there, there is no invariant position. (C) Sequence comparison of the TPR10 motif from the proteins shown at the top of this figure. Conserved residues outside the consensus are highlighted in yellow. Residue conservation is more extensive both within and outside of the consensus.