Fig. 3. Analysis of the role of BRG1 and BRM in large-scale chromatin remodelling of the MHC. SW13 cells (BRG1-BRM-negative) were treated with IFN
for 24 hours where indicated. HLA-DRA is detected in red and the CT6 in green. (A) SW13 cells without IFN
. (B) SW13 cells treated with IFN
. No external chromatin loops are observed. (C) SW13 cells, complemented with BRG1 and treated with IFN
. External chromatin loops carrying the MHC are clearly observed.