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Figure 6


Fig. 6. Model for chromatin changes during activation of the MHC by IFN{gamma}. The MHC is located within the CT6 before induction. GAS elements ({diamond}) and CIITA-binding sites (bullet) are shown. Binding of P-STAT1 ({diamondsuit}) leads to the release of the entire MHC, which loops outside the CT6 domain. After 2-4 hours the locus becomes hyperacetylated and accessible to transcription factors. CIITA (Figure 6) is synthesised and binds to the HLA genes 4-6 hours after IFN{gamma} induction to activate transcription.