Fig. 2. Interaction of -catenin and its partners. (A) A summary of the regions of -catenin that the partners described here bind to. Black bars indicate regions of -catenin bound by the different partners whereas red dots indicate the sites on -catenin that bind to the phosphorylated Ser/Thr residues of E-cadherin and the APC 20aa repeats. APC p-20aa represents the phosphorylated form of the APC 20aa-repeat region. The red stars indicate the sites on -catenin phosphorylated by CK1 and GSK-3 that create the binding site for -TrCP. (B) Structure of the -catenin armadillo repeat domain. The positions of the charged buttons (K312 and K435) are shown as circled Bs. The center of the groove of the armadillo repeat domain is shown as a dashed red line.