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Figure 2


Fig. 2. Putative model of actin regulatory pathways mediated by non-glutamate receptors. The actin-polymerizing activity of Arp2/3 and N-WASP depends on cortactin phosphorylation levels, which are controlled in a TrkB- and Src-dependent manner. Activation of EphB recruits and activates kalirin to spines, which through Rac and PAK results in activation of myosin.