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Figure 2


Fig. 2. Domain structure of beta-arrestins, showing binding sites and nuclear localization and nuclear export (NES) signals. beta-arrestins contain two major domains: an N domain and a C domain. The N domain (1-185) is indispensable for the nuclear localization of both beta-arrestins, and a functional NES (VxxxFxxLxL) is located at the C-terminus of beta-arrestin 2. The LIEF-binding motif for clathrin and the RxR-binding motif for AP2 within the C-terminus of beta-arrestins allow them to initiate clathrin-dependent endocytosis. The IP6-binding site resides in the C domain (233-251). The binding regions for Src (1-185), MDM2 (1-186), JNK3 (RRS sequence), I{kappa}B{alpha} (1-240) and TRAF6 are shown.