Fig. 6. Schwann cell migration is facilitated by activation of the Cdc2-caldesmon pathway. Cultures of Schwann cells from nerves with (A) or without (B) injury preconditioning were transfected with plasmids expressing dn-Cdc2, wt-Cdc2, caldesmon 7th mutant (Cald 7th), and pGFP. All GFP-positive cells that migrated to coverslips were counted. Horizontal lines in A and B indicate the mean number of cells (^**P<0.01, ^***P<0.001; n=5).