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Figure 3


Fig. 3. CO activates gene expression of cardiac mitochondrial biogenesis in mice. Real time RT-PCR for Wt and eNOS–/– mouse heart after 1-hour treatment with CO. (A) mRNA levels for PGC-1{alpha}; (B) NRF1; (C) NRF2{alpha} subunit; (D) Tfam. (E,F) No increase of PGC-1{alpha} or NRF1 mRNA in Wt heart after hypoxia (HH) or hyperbaric oxygen together with (HBO+CO). Values are the mean + s.e. normalized to GAPDH and multiplied by total RNA (mg/wet weight); *P<0.05 between strains at baseline; **P<0.05 compared with time zero; #P<0.05 compared with time zero and Wt.