Fig. 1. Structure and potential protein interaction partners of scaffold attachment factor, SAFB1 and SAFB2. (A) Cartoon of SAFB1 and SAFB2 proteins, showing the position of conserved domains, the epitopes used to raise the antisera and corresponding heterologous peptides used in mock pre-absorption of the antisera. (B) Summary of known protein interaction partners for these proteins (mainly based on SAFB1), grouped by family according to their role in transcription (left hand side) or RNA processing (right hand side). Protein families in each group implicated in intracellular signalling are on a hatched background; proteins tested in this study are asterisked, and proteins identified as stable components of the core SAFB1/SAFB2 complex by immunoprecipitation are in bold. See text for details.