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Figure 2


Fig. 2. MDCK ADAMTS12-expressing clones are refractory to the scattering effect of HGF stimulation. The control cMDCK clone shows reduced cell-cell adhesion and has a spindle-shape morphology upon treatment with HGF. By contrast, TS12-4 and TS12-22 still form epithelial-like colonies after 16 hours of incubation with HGF. A MDCK clone that expresses a catalytically inactive mutant version of ADAMTS12 (TS12-MUT) is also refractory to the scattering effect. Bar, 50 µm.