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Figure 1


Fig. 1. EGF ligand chimera constructs. (A) EGFR ligands are synthesized as integral membrane proteins that have variable membrane anchoring domains. Chimeras containing the receptor-binding domain of EGF (core) attached to the stem, transmembrane domain (TM) and cytoplasmic domain of either EGF or TGF-{alpha} were constructed as shown. (B) Amino acid sequence of each chimera showing the published cleavage site (arrowheads).