Fig. 8. Depletion of RILP alters the morphology of late endosomes. (A) In control cells, CD63 labelling is typically found in MVEs with varying numbers of intralumenal vesicles. Arrowheads indicate MVBs. (B) Cells depleted for RILP frequently contain more clustered CD63-positive endosomes. These endosomes are mostly devoid of intralumenal vesicles in comparison with controls. CD63 is labelled with 10-nm protein-A-gold; bars, 200 nm.