JCS -- Fritz et al. 120 (21): 3784 Figure IG6

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Fig. 6. Changes in FKBP12 and FKBP12.6 expression in embryonic RyR1^–/– mouse urinary bladder. (A) Semi-quantitative RT-PCR analysis of FKBP12 and FKBP12.6 mRNA in control and RyR1^–/– mouse myocytes. (B) Bar graph showing a significant diminution of FKBP12:GAPDH ratio in RyR1^–/– mouse myocytes in six different RNA extractions tested in triplicate. (C) Western blot analysis of FKBP12, FKBP12.6 and ${alpha}$ -actin expression in WT and RyR1^–/– mouse myocytes. (D) Bar graph of FKBP12 and FKBP12.6 fluorescence area per µg of protein obtained from four mice of each strain. ^*P<0.05.