Fig. 2. Measurement of specific force and susceptibility to eccentric injury. Maximal tetanic tension was measured in wild-type (WT) and K19–/– TA muscles before (black bars) and after (gray bars) injury caused by a single high-strain lengthening contraction. Data are reported as specific force (force normalized to cross-sectional area). Details are provided in Materials and Methods. Six animals were tested in each group. *P
0.001, significant difference between noninjured and injured; #P
0.003, significant difference between WT and K19–/–. The differences in the extent of injury between WT and K19–/– were not significant (see text).