Fig. 6. Presenilin and A peptide selectively immunolocalize to AVs within dystrophic neurites of PS1/APP mice. (A) Antibodies to PS1 strongly decorate neuritic plaques. (B) Immunogold-EM reveals that PS1 localizes principally to the limiting membranes of the AV, while mitochondria (Mito) or plasma membrane (PM) are unlabeled. (C) A42 immunoreactivity is detected within AVs of dystrophic neurites by silver-enhanced immunogold labeling. Reprinted with permission (Yu et al., 2005).