Fig. 7. Description of embryonic and adult lens phenotypes produced by mixing Cx50-S50P and wild-type lens fiber connexins. This model describes the embryonic and postnatal phenotypes of various mouse lenses created by breeding heterozygous mutant (Cx50^(S50P/+)–Cx46^(+/+)) and double knockout (Cx50^(–/–)–Cx46^(–/–)) mice. The drawing explains the proposed mechanism behind development of each unique phenotype based on the electrophysiological interactions documented herein.