Fig. 7. Rates of oocyte growth in wild-type, connexin-replacement and Cx37-knockout ovaries. Mean oocyte diameter was determined for the same follicles analyzed for Fig. 5. The chi-square test was used to compare the frequency distributions of follicle types between genotypes, whereas two-way ANOVA with Bonferroni test was used to test for interaction between genotype and oocyte size. Although oocytes of connexin-replacement follicles achieved the same mean diameter as oocytes of wild-type follicles in the early antral stage, mean oocyte diameter in Cx37-knockout follicles was significantly less (P<0.001).