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Figure 7


Fig. 7. ALK4 signalling is active in ALK5–/– EBs. Smooth muscle actin was detected by immunohistochemistry in sectioned EBs, stained as whole mounts. No striking difference was observed in SMA{alpha} expression between wild-type (A,A') and ALK5–/– (B,B') EBs, and, after incubation with SB-431542, SMA{alpha} was no longer detected in both wild-type (C,C') and ALK5–/– EBs (D,D'). Scale bars, 0.5 mm.