Fig. 5. Impairment of performance on object recognition in tPA-deficient mice is not mediated by the tPA/NR1 interaction. (A) In the novel-object-recognition test, WT mice exhibit good recognition performances as indicated by a strong preference towards the novel objects. By contrast, recognition memory is impaired in tPA-deficient mice, as indicated by the absence of preference towards the novel object. (B) In the same test, vaccination does not affect recognition memory. No differences were found among control, CFA-treated and NTD-NR1-vaccinated mice. ^*P<0.05.