Fig. 3. Transmission electron microscopy of adult control wild-type (A) and Inv-Dsg2 transgenic (B) epidermis. The granular cells appeared more compact and interconnected and corneocytes were thicker in the axial direction of the Inv-Dsg2 transgenic epidermis (brackets). Detached desmosomes with intercellular gaps were detected in the stratum corneum (^*). Arrows, desmosomes at the granular and stratum corneum interface; arrowheads, desmosome-like electron dense intercellular structures; d, desmosome; k, keratohyalin granules. Bars, 1 µm.