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Figure 2


Fig. 2. Ptc association within the Hh complex responds to activation state of the pathway. Ci, Cos2, Smo and Sxl immunoprecipitated from embryos expressing a different Ptc variant followed by western blot analysis for Sxl, Ptc and Smo. Efficiency of IP is relative to the 5% extract in the input lane (I). (A) Embryos expressing Ptc1130X. (B) Embryos expressing PtcD584N. (C) Embryos overexpressing wild-type Ptc. (D) Embryos expressing Ptc{Delta}Loop2.