Fig. 3. Increased cell surface distribution of -catenin in Timp3^–/– MECs following Wnt3A stimulation. (A) Representative confocal images from three different experiments. The colocalization of E-cadherin and -catenin was examined following treatment with W0 (control ligand) and Wnt3A in WT and Timp3^–/– MECs. (B) Representative confocal images of WT and Timp3^–/– mouse embryo fibroblasts treated with Wnt3A or control ligand. Arrows indicate nuclear localization of -catenin; arrowheads indicate increased membrane colocalization of E-cadherin and -catenin. Bars, 20 µm.