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Figure 3


Fig. 3. ADMA but not SDMA activates RhoA and inhibits Rac1 and Cdc42 in PAECs. The three graphs at the top show changes in the activity of RhoA, Rac1 and Cdc42 following 4 or 24 hours incubation with the drugs. Representative examples of western blots illustrating changes in Rho GTPases activity upon treatment with 100 µM ADMA or SDMA are shown below. The two graphs at the bottom show concentration-dependent changes in RhoA, Rac1 and Cdc42 activities in cells treated with SDMA or ADMA for 24 hours. *P<0.05; **P<0.01 (comparison with untreated controls).