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Figure 2


Fig. 2. BMP-9 binds to endogenous receptors in endothelial cells. (A,B) BAECs (A) or HUVECs (B) were affinity-labelled with [125I]BMP-9 and crosslinked ligand-receptor complexes were immunoprecipitated with specific antisera as indicated. BMP-9 predominantly binds to ALK1 and BMPR-II, but also to ALK2, ActR-IIA, ActR-IIB and endoglin. (C) Competition of [125I]BMP-9 binding to ALK1 in HUVECs with either excess unlabelled (cold) BMP-9, activin, BMP-7 or TGF-beta. Only cold BMP-9 can compete with [125I]BMP-9 binding to ALK1.