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Figure 5


Fig. 5. PDE4D41-166 expressing PMVECs possess greater membrane and cytosolic PKA activity. Forskolin (1 µM, 30 minutes) stimulated more PKA activity in PDE4D41-166-expressing cells than in control cells, in both membrane and cytosolic fractions. Total PKA activity represents maximal kinase activity in the presence of 2 µM cAMP in the reaction buffer (*P<0.05, n=4).