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Figure 5


Fig. 5. β-Dystroglycan and sarcoglycan expression in mdx mice expressing sarcolemmal {alpha}-dystrobrevin. (A,B) Palmitoylated {alpha}-dystrobrevin is specifically localized to the sarcolemma when expressed in the mdx mouse. However, the sarcolemmal {alpha}-dystrobrevin fails to restore normal levels of either β-dystroglycan or {alpha}-sarcoglycan, as determined by (A) immunofluorescence of TA muscle or (B) immunoblots of membrane proteins. Data were obtained from TgDB-RPS line 29. Scale bar, 50 µm.