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Figure 7


Fig. 7. Composition of Schwann cell BLs. Medial sciatic nerve sections from control and nmf417-mutant littermates were stained with antibodies against the indicated BL components. (A-D) Normal Schwann cells (A,C) produce little laminin (Ln) {alpha}1 and {alpha}5, and these were not upregulated in nmf417 nerves (B,D). (E,F) Non-myelinating Schwann cells normally express high levels of laminin {alpha}4, whereas myelinating Schwann cells express {alpha}4 at low levels. There was no increase in {alpha}4 on myelinating Schwann cells in nmf417 nerves. (G-N) The other primary components of endoneurial BLs, including laminin {gamma}1 (G,H), nidogen (I,J), collagen IV (K,L) and perlecan (M,N), were also present at comparable levels and with normal localization in the mutant nerves. Scale bar: 60 µm.