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Figure 3


Fig. 3. {alpha}Vβ5-dependent phagocytosis of apoptotic cells is mediated by Rac1. MFG-E8-opsonised ACs are captured by {alpha}Vβ5 integrins in DCs. The membrane protrusions that engulf the AC are triggered by the activation of Rac1 by the bimolecular Dock180-Elmo complex. A cascade that involves the adaptor proteins p130Cas and CrkII and a pathway that involves RhoG can lead to the recruitment and activation of Dock180-Elmo. Both pathways could be dependent on the engagement of co-receptors (such as BAI1 or Mer) by ACs.