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Figure 1


Fig. 1. Converting a cell into a probe. (A) The apex of a lectin-functionalized (often by binding concanavalin A) AFM cantilever is positioned above a cell. (B) The cantilever is gently pushed (generally with a force of <1 nN) for several seconds onto the cell. (C) The cantilever-bound cell is separated from the support and allowed to establish firm adhesion. (D) A phase-contrast image of a cell (arrow) bound to a tip-less cantilever.