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Figure 6


Fig. 6. Identification of a new securin destruction motif. (A) Alignment of βTrCP-binding motifs in securin proteins of various species. The arrow indicates Asp109 of securin (hSec1) that was mutated to Gly. (B) COS-7 cells were transfected with the indicated plasmids, and left untreated (C) or irradiated (UV) before harvesting. NP40 extracts were prepared and western blotted for the detection of the indicated proteins.