Fig. 7. GSK-3β inhibitors reverse the effect of UV radiation on securin expression. HeLa cells were left untreated (C) or UV-irradiated (UV) in the presence or absence of LiCl (A) or TDZD-8 (B). Inhibitors were added 1 hour before irradiation. Where indicated, extracts were treated with -PP. Equal amounts of extracts were resolved by SDS-PAGE. Immunoblotting was performed with anti-securin and anti--tubulin antibodies.