Fig. 2. Evolutionary conservation of yuri in Drosophila species. Yuri orthologs are detectable in 12 Drosophila species, but not outside the genus. The 100 kDa isoform is more conserved than the 30 kDa isoform. Similarity is computed as the global fraction of residues of the D. melanogaster protein that are present as similar residues in orthologs; these are lower than the local similarity scores from BLAST programs. The GLEANR data set contains consensus sets of predicted proteins for the 12 Drosophila species and was searched using the protein-to-protein BLASTP program. Because protein predictions are not available (NA) for non-Drosophila species, the 30 kDa search was repeated for all sequenced insect species using the protein-to-DNA TBLASTN program. Tree image is from FlyBase (Crosby et al., 2007).