Fig. 1. Evolutionary conservation of caveolins. Caveolin phylogeny. Phylogenetic analyses were performed with Bayesian interference, ML, NJ and parsimony methods from the alignment of caveolin sequences to R54 to P158 in HsCav1 to P158. The ML tree topology was used for the display (with a midpoint rooting) and the node support is given in the following order (from top to bottom): Bayesian (posterior probability, PP), ML, NJ and parsimony (bootstrap support, BS). Asterisks (^*) indicate a PP<95 or a BS<50. Prot, protostomians. To simplify the display, several nodes with a good support (PP>95 and BS80) are marked by a filled circle; similarly the support for poorly supported nodes or for a few terminal nodes with average support was omitted. For the roots of the `CavY extended' and `Prot G1' groups the node support is indicated for two datasets, with the left-hand column derived from the complete dataset and the right-hand column derived from a reduced dataset where the two nematode sequences of the `Prot G3' group were removed. For the root of the `CavY extended' group the BS with the NJ analysis was <50 and the support with the Interior Branch Test is indicated in parentheses; the support on the left was for a `CavY extended' group including the two nematode sequences of the `Prot G3' group. The names of the species are colour-coded as indicated in the top-right corner of the figure.