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Figure 2


Fig. 2. Sarcolemma levels of TRPC1 and caveolin-3 are increased in mdx muscle. (A-D) Sample micrographs of muscle cryosections from WT and mdx mice double stained by immunofluorescence for TRPC1 and caveolin-3. Scale bar: 50 µm. (E,F) Quantitation of the fluorescence in the sarcolemma region revealed increased intensity of staining for both TRPC1 and caveolin-3 in the mdx group. n=4 mice per group, 15 membrane segments per mouse. *P<0.05; ***P<0.001.