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Figure 7


Fig. 7. TRPC6 promotes dendritic growth in vivo. (A) The total lysates of P14 mouse hippocampi from wild-type or TRPC6 transgenic mice blotted with the antibodies to TRPC6, {alpha}-tubulin, phosphorylated CaMKIV, total CaMKIV, phosphorylated CREB and total CREB. (B) Quantification of TRPC6, phosphorylated CaMKIV (p-CaMKIV) and phophorylated CREB (p-CREB) in the hippocampi of wild-type and TRPC6 transgenic mice. *P<0.05 versus wild-type. (C,D) Representative projections of CA1 hippocampal pyramidal neurons from wild-type (WT) and TRPC6 transgenic (TG) mice. (E,F) Quantification of dendritic tips (E) and dendritic length (F) of the neurons shown in C and D. Data are the means ± s.e.m. **P<0.01 versus wild type.