JCS -- Huveneers et al. 121 (15): 2452 Figure IG9

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Fig. 9. A model for the role of ${alpha}$ 5β1 integrin in reorganization of focal adhesions, contractility, cell morphology and fibronectin-matrix assembly. (A) Adhesion to immobilized (stretched) RGD-containing ECM components such as vitronectin (VN) or fibronectin (FN) through ${alpha}$ vβ3 integrin in the absence of ${alpha}$ 5β1 integrin promotes the formation of randomly distributed cell-matrix adhesions leading to an epithelial-like, flat, circular morphology. (B) In the presence of ${alpha}$ 5β1 integrin, binding of compact soluble fibronectin dimers to this integrin promotes the dynamic centripetal redistribution of focal adhesions. Together with the high activity of RhoA that is supported in the presence of ${alpha}$ 5β1 integrin, this allows the cytoskeletal organization that drives fibronectin fibrillogenesis.